Continual use (even at therapeutic doses) may well produce the development of physical dependence: discontinuation with the therapy could result in withdrawal or rebound phenomena.Diazepam is N-demethylated by CYP3A4 and 2C19 into the Lively metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 into the Lively metabolite temazepam.Diazepa